A young man in financial difficulties persuades his wife to help him blackmail a supposedly wealthy man.

Handle with Care is a 1922 silent comedy.

While Jim Barlow is hiding from the cops, his wife Ann goes to a mission The minister, Reverend John Matthews, gives her the address of a good Samaritan, Dr. LeRoy Clifford . When her child is hit by an automobile, she takes him to Clifford, who proceeds to operate right at his house. Meanwhile, one of Barlow's former associates, known as the Weasel tracks him down and convinces him to come on a job. The home they break into is Clifford's, while he is in the middle of working on Barlow's little boy. Barlow helps the doctor by holding a spotlight so he can complete the operation. The Library of Congress holds a 35 mm shortened version.

Jacqueline Floriot is driven from her home by her husband Louis, a deputy attorney of Paris, because of his unjust suspicions regarding her relations with another man. Floriot forbids Jacqueline to see her baby boy, who is dangerously ill, and when informed that the boy believes her dead, she attempts suicide.

When Pollyanna is orphaned, she's sent to live with her crotchety Aunt Polly. Pollyanna discovers that many of the people in her aunt's New England hometown are as ill-tempered as her aunt. But Pollyanna's incurable optimism - exemplified by her "glad game", in which she looks for the bright side of every situation - brings a change to the staid old community.

A young woman, confronted by four options for proceeding in her life, is granted the ability to see what results would come from her choice of of the options. After she sees her future along three of the roads, she makes her choice.

A prologue shows an alchemist about to be burned at the stake. Before dying, he claims that his theory is correct: in an effort to overcome external conditions, man develops his character. In modern times, Harry Thorn loves Grace Dupont, but after losing his money he drifts toward crime. He steals a necklace, and when Grace finds out she cancels their engagement. Harry decides to give himself up, thereby finally establishing some strength of character. When he gets out of jail, Grace takes him back, but Harry has to face one more temptation. Alice Farley, who loves him but whom he has spurned, tries to lure him back to crime, but with Grace's help Harry manages to resist.

Franti, an organ grinder of the poor districts of New York, has a daughter, Isola, who sings to his street piano's accompaniment.