Millionaire Mason Murphy renovates the haunted Mayhew mansion. He plans a tremendous lunar eclipse viewing party to celebrate his return to his hometown of River Ridge Iowa. At the party, magic runs out of control and the party guests are murdered one by one.

The seemingly invincible Spider-Man goes up against an all-new crop of villains—including the shape-shifting Sandman. While Spider-Man’s superpowers are altered by an alien organism, his alter ego, Peter Parker, deals with nemesis Eddie Brock and also gets caught up in a love triangle.