A lady cop infiltrates an all-female criminal gang.

A U.S. Senator is spirited away to a secret New Mexico medical lab after a serious car crash. His injuries are completely healed by a secret organization that has developed advanced medical technology. What does the organization want in exchange for saving his life? Meanwhile, a reporter who witnessed the accident decides to investigate the senator's disappearance.

Lt. Col. George Armstrong Custer has been reinstated and assigned to command the 7th Cavalry Regiment at Fort Hays. The regiment has become a ragtag outfit of thieves and ruffians and Custer must whip the soldiers into shape to fight, the Kiowa, Sioux and Blackfoot tribes who confront them. These tribes are being supplied shotguns by a white gunrunner and Custer and his men must rescue General Terry and the Fifth Cavalry Regiment from annihilation when they are ambushed and trapped by a large Kiowa war party.

Richard Kimble is falsely convicted of his wife's murder and given the death penalty. En route to death row, Kimble's train derails and crashes, allowing him to escape and begin a cross-country search for the real killer, a "one-armed man". At the same time, Dr. Kimble is hounded by the authorities, most notably dogged by Police Lieutenant Philip Gerard.