The film follows John Crenshaw as he accompanies his girlfriend and her students on a weekend nature-photography expedition deep into the woods. What should be an educational and fun-filled weekend turns into horror as the group is besieged by an unspeakable evil - a horde of hideously disfigured, mutated humans with an insatiable taste for blood. As things go from bad to worse, Crenshaw becomes their only hope if they are going to get out alive.

Revolving around a group of twentysomething singles as they navigate the difficult, sometimes rewarding, often confusing world of dating. Loyal and devoted to one another, these friends are never too busy to help a member of the group who might be in need. In fact, their companionship often extends into a more intimate setting - the bedroom.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.