After a serial killer imitates the plots of his novels, successful mystery novelist Richard "Rick" Castle receives permission from the Mayor of New York City to tag along with an NYPD homicide investigation team for research purposes.

The everyday lives of office employees in the Scranton, Pennsylvania branch of the fictional Dunder Mifflin Paper Company.

Bizarre things start happening in the little New Mexico town where UFOs were spotted in 1947. Cut to 1999, when a cute high-school student saves the life of a teenage waitress. Surrounded by cliques of clever, angst-filled classmates, the two form a bond that threatens the survival of a secret universe involving superhuman powers, a yen for hot sauce and an alien gene pool.