CSI: Miami follows Crime Scene Investigators working for the Miami-Dade Police Department as they use physical evidence, similar to their Las Vegas counterparts, to solve grisly murders. The series mixes deduction, gritty subject matter, and character-driven drama in the same vein as the original series in the CSI franchise, except that the Miami CSIs are cops first, scientists second.

Heather and Heidi play volleyball for their school team, when their family decides that they need to go to a bigger school so that they will have a better chance for scholarships. But at the new school, the twins are discovered by the basketball coach. Inspired by the true story of Heather and Heidi Burge.

After his mother's death, Jed Perry and his father move to northern California, where Jed enrolls at Evergreen Academy. Along with Jed, only two other boys attend the formerly all-girls school.

Reverend Eric Camden and his wife Annie have always had their hands full caring for seven children, not to mention the friends, sweethearts and spouses that continually come and go in the Camden household.