Although awkward college student Todd Howard is particularly adept at science, he's paying for school with an athletic scholarship that he will lose should he not fare well in an upcoming boxing tournament. Luckily for Todd, he has inherited the same family curse that once turned his cousin into a werewolf. As he transforms into the hairy, fanged, howling monster, he finds both his physical agility and his popularity skyrocketing -- but at what cost?

At Adams College, the jocks rule the school from their house on high, the Alpha Beta fraternity. So when a group of socially-challenged misfits try to go Greek, they're instantly rejected by every house on campus. Deciding to start their own fraternity to protect their outcast brothers, the campus nerds soon find themselves in a battle royale as the Alpha Betas try to crush their new rivals.