Christine Collins is overjoyed when her kidnapped son is brought back home. But when Christine suspects that the boy returned to her isn't her child, the police captain has her committed to an asylum.

Newlywed Melinda Gordon tries to help the dead communicate with loved ones, but sometimes the messages she receives are intense and confusing. Most of Melinda's efforts involve resolving conflicts that are preventing the spirits from passing over.

Bizarre things start happening in the little New Mexico town where UFOs were spotted in 1947. Cut to 1999, when a cute high-school student saves the life of a teenage waitress. Surrounded by cliques of clever, angst-filled classmates, the two form a bond that threatens the survival of a secret universe involving superhuman powers, a yen for hot sauce and an alien gene pool.

After a terrible air disaster, survivor Max Klein emerges a changed person. Unable to connect to his former life or to wife Laura, he feels godlike and invulnerable. When psychologist Bill Perlman is unable to help Max, he has Max meet another survivor, Carla Rodrigo, who is wracked with grief and guilt since her baby died in the crash which she and Max survived.