After breaking up with her girlfriend, a nightclub singer, Jane, answers a personal ad from Robin, a real estate agent with AIDS, seeking a cross-country travel partner. On their journey from New York City to Los Angeles, the two stop by Pittsburgh to pick up Jane's friend Holly, who is trying to escape an abusive relationship. With three distinct personalities, the women must overcome their differences to help one another.

Former prostitute Molly Stewart works as a police photographer. When an old friend, a groupie in pursuit of the lead singer of a rock band, is found murdered with a guitar string, she goes undercover as Angel to find the killer.