During the 1980s, a failed stand-up comedian is driven insane and turns to a life of crime and chaos in Gotham City while becoming an infamous psychopathic crime figure.

An aging comic icon, Jackie Burke, has seen better days. Despite his efforts to reinvent himself and his comic genius, the audience only wants to know him as the former television character he once played. Already a strain on his younger brother and his wife, Jackie is forced to serve out a sentence doing community service for accosting an audience member. While there, he meets Harmony, the daughter of a sleazy Florida real estate mogul, and the two find inspiration in one another, resulting in surprising consequences.

Given superstrength and durability by a sabotaged experiment, a wrongly accused man escapes prison to become a superhero for hire.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.