In 1926, Newt Scamander arrives at the Magical Congress of the United States of America with a magically expanded briefcase, which houses a number of dangerous creatures and their habitats. When the creatures escape from the briefcase, it sends the American wizarding authorities after Newt, and threatens to strain even further the state of magical and non-magical relations.

Deep underground, a lone scientist mans a discarded research facility struggling to deal with extreme boredom, a desperate voiceless companion and a mystery he'd really rather not have to solve.

Four characters living in one neighborhood in London - all living dramatically different lives, all of them on the edge - see their stories unfold.