Judith is a doctor who is very committed to her profession. Aiming to become a cardiologist, she performs part of her residency in a chronically understaffed hospital emergency room. During a particularly difficult shift, she makes a mistake that causes the death of a patient. Judith is devastated and doubts whether she is suited to the profession. Her fellow doctors, including her partner Mark, advise her to just carry on as before. While Judith’s actions are investigated, she is assigned to ambulance duty. Being in a new environment and having some distance to the clinical routine allow her to see things in a new light.

Teenage girl Lys is discovered inside the reactor of the newly build TERRA Power Plant and finds she is developing special powers that connect her to the energy of all living things.

The SOKO Stuttgart team investigates analytically and with sensitivity in the likeable state capital. The exciting cases of the series lead them to bizarre crime scenes and to different milieus.