Opposite Lives tells the story of Miguel (Leo Rosa), a young rich man of a traditional family, and Joana (Maytê Piragibe), a student and tourist guide who lives in a slum. Although dating an elegant and rich fashion designer, Erínia (Lavínia Vlasak), Miguel and Joana fall in love for each other and they decide to get married.

Maria Auxiliadora is a 24 year-old woman very poor, that she lives Joana, her 7 year-old daughter close to. Needing go look for the result of Joana's exam in the hospital, Maria asks the priest of the local church that takes care of her to return. In spite of Joana's insistence to go with the mother Maria insists that she is with the priest, because she distrusts that her daughter suffers of a serious disease. To entertain the girl while it awaits the mother's return, the priest decides to tell her a mother's history that dedicated her life to the son: Mary, mother of Jesus Christ.

The central story is focused on the daughters of Lulu de Luxemburgo - Tatiana , Alessandra and Ramona, who fight among themselves for Jardim do Éden resort, which their father, Fausto Cavalcante , left behind after cheating his two partners, Arthur Brandão and Manolo Gutierrez. With the disappearance of Fausto, the whole family, which was separated and spread across the world (between Rome, Los Angeles and Las Vegas), returns to Brazil.