A small town teenager in the 1960s believes her dreams of becoming a famous singer will come true when her rock star idol gets stranded in town. But a leak in a nearby chemical plant that is believed to be causing mass mutations threatens to turn her dream into a nightmare.

A high concept thriller that tells the story of Dr. Ephraim Goodweather, the head of the Center for Disease Control Canary Team in New York City. He and his team are called upon to investigate a mysterious viral outbreak with hallmarks of an ancient and evil strain of vampirism. As the strain spreads, Eph, his team, and an assembly of everyday New Yorkers, wage war for the fate of humanity itself.