A university research scientist, about to lose funding and status, has a lab accident and discovers he can see people's true intentions -- making his situation even worse.

In 1948 Manhattan, a diverse group of people are committed to making the fledgling Empire Network a success. Among them: a naive young woman who's hired as a script girl; an idealistic programmer; and an aspiring director who hopes to make Empire "the network that takes risks and makes new stars." Then there's Empire's president, an eccentric scientist whose bride raises eyebrows at the network.

The series follows the ventures of a Missing Persons Unit of the FBI in New York City.

ER explores the inner workings of an urban teaching hospital and the critical issues faced by the dedicated physicians and staff of its overburdened emergency room.