A boy named Eli with a rare autoimmune disorder is confined to a special experimental clinic for his treatment. He soon begins experiencing supernatural forces, turning the supposedly safe facility into a haunted prison for him and his fellow patients.

In the near future, a weary Logan cares for an ailing Professor X in a hideout on the Mexican border. But Logan's attempts to hide from the world and his legacy are upended when a young mutant arrives, pursued by dark forces.

Two rival politicians compete to win an election to represent their small North Carolina congressional district in the United States House of Representatives.