Flight attendant Cassandra Bowden wakes in her hotel room hungover from the night before in Dubai with a dead body lying next to her. Afraid to call the police, she continues her morning as if nothing happened. In New York, she is met by FBI agents who question her about her recent layover in Bangkok. Still unable to piece the night together, she begins to wonder if she could be the killer.

Andrew returns to his hometown for the funeral of his mother, a journey that reconnects him with past friends. The trip coincides with his decision to stop taking his powerful antidepressants. A chance meeting with Sam - a girl also suffering from various maladies - opens up the possibility of rekindling emotional attachments, confronting his psychologist father, and perhaps beginning a new life.