Recently divorced entrepreneur George Lopez is successful in his business ventures but caught between two cultures in his personal life. He struggles to find balance between the parenting demands of his Anglo ex-wife, Mackenzie, and the cultural expectations of his Latina mother, Alma. His freeloading Uncle Tio and Cousin Junior further complicate his life, which includes 11-year-old son Harper. Outside the home, the successful businessman gives back to the community by teaching history to a multicultural class at a Los Angeles night school; there he is supervised by tough, attractive Assistant Principal Concepcion.

The series follows the ventures of a Missing Persons Unit of the FBI in New York City.

A boy named George Jung grows up in a struggling family in the 1950's. His mother nags at her husband as he is trying to make a living for the family. It is finally revealed that George's father cannot make a living and the family goes bankrupt. George does not want the same thing to happen to him, and his friend Tuna, in the 1960's, suggests that he deal marijuana. He is a big hit in California in the 1960's, yet he goes to jail, where he finds out about the wonders of cocaine. As a result, when released, he gets rich by bringing cocaine to America. However, he soon pays the price.

A lawyer and her partner run from the Colombian Mafia and the corrupt U.S. marshals and attorneys assigned to protect them.

Life’s good for deliveryman Doug Heffernan, until his newly widowed father-in-law, Arthur, moves in with him and his wife Carrie. Doug is no longer the king of his domain, and instead of having a big screen television in his recently renovated basement, he now has a crazy old man.

ER explores the inner workings of an urban teaching hospital and the critical issues faced by the dedicated physicians and staff of its overburdened emergency room.

Dr. Mark Sloan is a good-natured, offbeat physician who is called upon to solve murders.

Cole Hickel, a Marine, pursues his daughter's killer when he is allowed to go back to Paraguay because of "diplomatic immunity."

Follow the lives of a group of teenagers living in the upscale, star-studded community of Beverly Hills, California and attending the fictitious West Beverly Hills High School and, subsequently, the fictitious California University after graduation.

A stand-up comedian and his three offbeat friends weather the pitfalls and payoffs of life in New York City in the '90s. It's a show about nothing.

Basket-case network news producer Jane Craig falls for new reporter Tom Grunnick, a pretty boy who represents the trend towards entertainment news she despises. Aaron Altman, a talented but plain correspondent, carries an unrequited torch for Jane. Sparks fly between the three as the network prepares for big changes, and both the news and Jane must decide between style and substance.