In a moment of desperation, Ruby Chase makes a vow of servitude to a monster (Frank). She breaks her vow by committing suicide, setting Frank on a course of bloody revenge against the people she loved the most.

A young man with a violent past enters a mysterious clinic where the patients wildly transform their bodies and minds using genetic engineering.

Starting over isn’t easy, especially for small-town guy John Nolan who, after a life-altering incident, is pursuing his dream of being an LAPD officer. As the force’s oldest rookie, he’s met with skepticism from some higher-ups who see him as just a walking midlife crisis.

Agent Phil Coulson of S.H.I.E.L.D. (Strategic Homeland Intervention, Enforcement and Logistics Division) puts together a team of agents to investigate the new, the strange and the unknown around the globe, protecting the ordinary from the extraordinary.

Los Angeles, 1958: a detective holes up in a downtown hotel awaiting killers to come get him. During the course of one night he will meet various occupants of the hotel and the truth of how he came to be in his present situation will be revealed.

Dr. Daniel Pierce, a neuroscientist and professor, is recruited to help the federal government crack difficult cases. His intimate knowledge of human behavior and masterful understanding of the mind give him an extraordinary ability to read people, but his eccentric view of the world and less-than-stellar social skills can often interfere with his work.

Jessica Day is an offbeat and adorable girl in her late 20s who, after a bad breakup, moves in with three single guys. Goofy, positive, vulnerable and honest to a fault, Jess has faith in people, even when she shouldn't. Although she's dorky and awkward, she's comfortable in her own skin. More prone to friendships with women, she's not used to hanging with the boys—especially at home.

After 10 years in prison, Driver is now a free man with a single focus - hunting down the people responsible for brutally murdering his brother.

Kenneth Bianchi is a security guard whose attempts to become a police officer are repeatedly thwarted. He moves to California to live with his cousin Angelo and dates a string of women, becoming increasingly preoccupied with sex. Eventually the cousins decide to start an escort agency. After violently killing a prostitute they thought had betrayed them, Kenneth and Angelo begin committing a series of crimes that become a media sensation.

Young, innocent, and quirky June (Felicia Day), a violinist, spends her days working in an oddball Venice coffee shop, her nights rehearsing for a professional music career, and all-hours daydreaming about the beautiful man that's destined just for her. When she actually meets him in her own apartment building, she finds out Jack (Chris Henry Coffey) is engaged to the quintessential gorgeous bitch, Quinn (Cindy Dolenc). The conflict ensues and the romance is tested. Whether it's indulging her loony Grandma (Ellen Geer) through rehearsals of her own funeral, or dealing with the overzealous video-store manager (Ted Michaels) and his crush, June stumbles through her potential love life, her best friend Mary at her side.

The series follows the ventures of a Missing Persons Unit of the FBI in New York City.

Adrian Monk was once a rising star with the San Francisco Police Department, legendary for using unconventional means to solve the department's most baffling cases. But after the tragic (and still unsolved) murder of his wife Trudy, he developed an extreme case of obsessive-compulsive disorder. Now working as a private consultant, Monk continues to investigate cases in the most unconventional ways.

An ex-lawman travels to Mexico, searching for the heir to a Los Angeles fortune, while confronting his own complicated past. But what he finds in Baja challenges him to the core.