The detectives of the Organized Crime Control Bureau work to dismantle New York City's most vicious and violent illegal enterprises.

The Fugitive Task Force relentlessly tracks and captures the notorious criminals on the Bureau's Most Wanted list. Seasoned agents oversee the highly skilled team that functions as a mobile undercover unit that is always out in the field, pursuing those who are most desperate to elude justice.

A con man on the run from a vicious gangster takes cover from his past by assuming the identity of his prison cellmate, Pete, “reuniting” with Pete’s estranged family, a colorful, dysfunctional group that threatens to drag him into a world just as dangerous as the one he’s trying to escape - and, just maybe, give him a taste of the loving family he’s never had.

A drama about a multi-generational family of cops dedicated to New York City law enforcement. Frank Reagan is the New York Police Commissioner and heads both the police force and the Reagan brood. He runs his department as diplomatically as he runs his family, even when dealing with the politics that plagued his unapologetically bold father, Henry, during his stint as Chief.

In the unreal world of Sacred Heart Hospital, John "J.D." Dorian learns the ways of medicine, friendship and life.

Dr. Mark Sloan is a good-natured, offbeat physician who is called upon to solve murders.

In cases ripped from the headlines, police investigate serious and often deadly crimes, weighing the evidence and questioning the suspects until someone is taken into custody. The district attorney's office then builds a case to convict the perpetrator by proving the person guilty beyond a reasonable doubt. Working together, these expert teams navigate all sides of the complex criminal justice system to make New York a safer place.

The "Vampire Killer" leaves his victims drained of blood, while a detective tries to catch him.