Follow the lives of a group of students at what is possibly the world’s worst community college in the fictional locale of Greendale, Colorado.

Rules of Engagement is a comedy about the different phases of male/female relationships, as seen through the eyes of a newly engaged couple, Adam and Jennifer, a long-time married pair, Jeff and Audrey, and a single guy on the prowl, Russell. As they find out, the often confusing stages of a relationship can seem like being on a roller coaster. People can describe the ride to you, but to really know what it's like you have to experience it for yourself.

The story of two brothers who lead totally different lives. Jake Hunt enjoys life to the fullest in Thailand, while his shy brother Oliver deals with his own depressions back home in the USA. Their dominant mother wants Jake back home and for this reason, Oliver is sent to Thailand to retrieve his brother. Once there, Oliver finds himself in Jake's bizarre life and falls in love with a beautiful girl, Lek. However, it is not a coincidence that she and Oliver have met

Single working mom Christine Campbell has just learned that her ex is dating a much younger woman with the same first name. To avoid any confusion, the new girlfriend is dubbed New Christine, which leaves her with the unfortunate nickname Old Christine.

Deputy Police Chief Brenda Leigh Johnson transfers from Atlanta to LA to head up a special unit of the LAPD that handles sensitive, high-profile murder cases. Johnson's quirky personality and hard-nosed approach often rubs her colleagues the wrong way, but her reputation as one of the world's best interrogator eventually wins over even her toughest critics.

In the unreal world of Sacred Heart Hospital, John "J.D." Dorian learns the ways of medicine, friendship and life.

Two quirky, cynical teenaged girls try to figure out what to do with their lives after high school graduation. After they play a prank on an eccentric, middle aged record collector, one of them befriends him, which causes a rift in the girls' friendship.

Will Truman and Grace Adler are best friends living in New York, and when Grace's engagement falls apart, she moves in with Will. Together, along with their friends, they go through the trials of dating, sex, relationships and their careers, butting heads at times but ultimately supporting one another while exchanging plenty of witty banter along the way.