Dr. Beaumont Rosewood, Jr. is a brilliant private pathologist who uses wildly sophisticated technology and his drive to live life to the fullest to help a tough-as-nails detective and the Miami PD uncover clues no one else can see.

Overbearing mom, Jackie, travels cross-country to be with her son, Angelo, after he drops out of college to become a surfer. She meets a surf instructor who convinces her to try to accept her son's wishes and allow him to follow his dreams.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.