Benjamin Franklin Gates and Abigail Chase re-team with Riley Poole and, now armed with a stack of long-lost pages from John Wilkes Booth's diary, Ben must follow a clue left there to prove his ancestor's innocence in the assassination of Abraham Lincoln.

Washington, D.C. psychologist Carol Bennell and her colleague Dr. Ben Driscoll are the only two people on Earth who are aware of an epidemic running rampant through the city. They discover an alien virus aboard a crashed space shuttle that transforms anyone who comes into contact with it into unfeeling drones while they sleep. Carol realizes her son holds the key to stopping the spread of the plague and she races to find him before it is too late.

Told from the points of view of both the Baltimore homicide and narcotics detectives and their targets, the series captures a universe in which the national war on drugs has become a permanent, self-sustaining bureaucracy, and distinctions between good and evil are routinely obliterated.

After losing in the ALCS the year before, the Cleveland Indians are determined to make it into the World Series this time! However, they first have to contend with Rachel Phelps again when she buys back the team.