1596. Anne, a deaf girl, bullied by the maids and mistresses who look after her, finds solace when she comes across a magical tree: a portal to the present, where she meets Jo and Rachel, who help her overcome her disability in a way she could never have imagined.

The series followed Henrietta "Hettie" Hubble, (Mildred's younger cousin), through her years at Cackles Academy. Mildred is seen in the first episode accompanying her cousin to Cackles, before magically returning home. Hettie quickly becomes friends with Mona Hallow (Ethel's younger sister) and Crescentmoon "Cressie" Winterchild. The new enemy of Cackles is filled by Belladonna Bindweed and the sidekick is filled by Cynthia Horrocks. Miss Hardbroom and Miss Cackle return, and are joined by new members of staff Caspian Bloom, Miss Swoop and Miss Widget/Miss Nightingale.

An American girl, Daphne, heads to Europe in search of the father she's never met. But instead of finding a British version of her bohemian mother, she learns the love of her mom's life is an uptight politician. The only problem now is that her long-lost dad is engaged to a fiercely territorial social climber with a daughter who makes Daphne's life miserable.

Mildred Hubble is a young witch attending Cackles Academy. She's called the "Worst Witch" because she's always caught getting into trouble.