108 years after the last man died in chemical warfare, only women still live on Earth. Charlie and her sister Lucie no longer ask the question: they have never known men. Society has reorganized, relegating men to museums of natural history. When Charlie accompanies Lucie to her JAPP (Day of Appeal and Preparation for Procreation), the only chance in a woman's life to be inseminated in a sperm bank, they come face to face with Gabrielle who trains them in search of the last surviving man...

When a teenager suddenly disappears without a trace, the case is assigned to an alcoholic police officer who maintains a complicated relationship with his own troubled teenage son, suspected of drug trafficking.

Paris, in the early 1990s: a group of young activists is desperately tied to finding the cure against an unknown lethal disease. They target the pharmaceutical labs that are retaining potential cures, and multiply direct actions, with the hope of saving their lives as well as the ones of future generations.