James Herriot is a vet in Yorkshire, England, during the 1940's. He is assigned to the practice of Siegfried Farnon, who—together with his mischievous brother Tristan—already have a successful business. James undergoes a variety of adventures during his work, which are just as often caused by the characters of the county, including the Farnon brothers, as the animals in his care.

Art has a rabbit, Ern a guinea pig and Abe, a mouse. They're off to astound the world of the Fancy with a triple triumph... but what about the Entwhistles!