A revolution in Iran halts a heroin shipment, but an alliance of crime families is set on getting it to the US. They decide to run the drug through an unsuspecting network of good-natured, local smugglers in Naples, while an international anti-narcotics agent rushes to shut their operation down. Betrayals and divided loyalties lead to a final, bloody confrontation in America.

Don Vincenzo is a well respected boss from Naples, but he protects people from other criminals, like gypsies, loan sharks and Don Bufalo...but as they say in Naples, a Mammasantissima either ends in jail or inside a grave.

Don Salvatore Savastano, a boss involved in the smuggling of contraband cigarettes, is forced to watch four masked robbers kill his wife and his only son in a restaurant where he and his family are celebrating the young boy's first Holy Communion. From that moment on Don Salvatore has no other purpose in life but to get his revenge on the four assassins.