Frank Corvin, ‘Hawk’ Hawkins, Jerry O'Neill and ‘Tank’ Sullivan were hotdog members of Project Daedalus, the Air Force's test program for space travel, but their hopes were dashed in 1958 with the formation of NASA and the use of trained chimps. They blackmail their way into orbit when Russia's mysterious ‘Ikon’ communications satellite's orbit begins to degrade and threatens to crash to Earth.

On a flight transporting dangerous convicts, murderer Ryan Weaver manages to break free and cause complete chaos throughout the plane. As various people on board fall victim to Weaver, it is ultimately down to flight attendant Teri Halloran to keep the aircraft from crashing, with on-ground support from an air traffic controller. While Halloran struggles to pilot the plane, Weaver continues to terrorize the surviving members of the crew.

Dr. Mark Sloan is a good-natured, offbeat physician who is called upon to solve murders.

A psychologist, a psychiatrist and a prison warden open up a long-closed prison, unaware that the ghost of an electrocuted convict haunts it.