Dr. Beaumont Rosewood, Jr. is a brilliant private pathologist who uses wildly sophisticated technology and his drive to live life to the fullest to help a tough-as-nails detective and the Miami PD uncover clues no one else can see.

Jordan Turner is an experienced 911 operator but when she makes an error in judgment and a call ends badly, Jordan is rattled and unsure if she can continue. But when teenager Casey Welson is abducted in the back of a man's car and calls 911, Jordan is the one called upon to use all of her experience, insights and quick thinking to help Casey escape, and not just to save her, but to make sure the man is brought to justice.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.