The turbulent life and professional career of vaudeville actor and silent screen horror star Lon Chaney (1883-1930), the man of a thousand faces; bearer of many personal misfortunes that even his great success could not mitigate.

Maggi continues her forever-ever efforts to crash Manhattan's top society, while Jiggs still mingles with his old construction cronies at the bar of Dinty Moore on 10th Avenue.

Sach just lost his job as an assistant to a private detective, but he wasn't paid. Slip goes with him down to the detective's office to demand payment, but finds the office empty. A woman enters the office and mistakes Slip for the detective and convinces him to take on a case to find her sister after offering a $50 retainer.

Steve Bell, Tommy, Pig, Ape, and String are run of town. Steve, while hopping a freight card and trying to avoid the brakeman, is killed. The boys meet Steve's mother, Alice Bell and Tommy is given a job in the storage garage which she owns jointly with Mack Steward. Steve's brother Don Bell is working with some gangsters by tipping them off on valuable merchandise that can be hijacked. Pig, Ape and String overhear Don's plans to use Tommy as the fall guy in the next hijacking.

A detective investigating kidnapping case discovers the victim, who may be a zombie.

Jeff grows up near Basin Street in New Orleans, playing his clarinet with the dock workers. He puts together a band, the Basin Street Hot-Shots, which includes a cornet player, Memphis. They struggle to get their jazz music accepted by the cafe society of the city. Betty Lou joins their band as a singer and gets Louie to show her how to do scat singing. Memphis and Jeff both fall in love with Betty Lou.

Banished from various U.S. protectorates in the Pacific, a saloon entertainer uses her femme-fatale charms to woo politicians, navy personnel, gangsters, riff-raff, judges and a ship's doctor in order to achieve her aims.