In the near future, planet Earth is permanently altered following the sudden—and tumultuous—arrival of seven unique alien races. In the boom-town of Defiance, the newly-formed civilization of humans and aliens must learn to co-exist peacefully.

Detective Win Garano is asked to reopen a twenty-year-old murder case, and soon finds himself endangered by the political ambitions of a district attorney.

Charlie Grace is a Los Angeles private eye with a daughter named Jenny, works along with other cops, including his partner, Crawford, to solve different multiple mystery cases.

Ambitious stage mother Rose wants desperately for her daughter, June, to become the vaudeville star she never was. With the help of savvy but kind-hearted agent Herbie, Rose realizes her aspirations for June, but when her star rebelliously elopes, June's shy sister, Louise, reluctantly steps into the spotlight, transforming herself into the legendary burlesque star Gypsy Rose Lee.

Frank Cross is a wildly successful television executive whose cold ambition and curmudgeonly nature has driven away the love of his life. But after firing a staff member on Christmas Eve, Frank is visited by a series of ghosts who give him a chance to re-evaluate his actions and right the wrongs of his past.

The eccentric and childish Pee-wee Herman embarks on a big adventure when his beloved bicycle is stolen. Armed with information from a fortune-teller and a relentless obsession with his prized possession, Pee-wee encounters a host of odd characters and bizarre situations as he treks across the country to recover his bike.