Set during the 1960s in the fictional North Yorkshire village of Aidensfield, this enduringly popular series interweaves crime and medical storylines.

For years, a blackmailer has been preying on the weaknesses of others throughout London. When Holmes hears of the utter misery this mystery man is creating, he adopts a campaign to thwart his evil scheming. The campaign astonishes Dr. Watson by its strangeness and finds Holmes falling in love.

Sherlock Holmes uses his abilities to take on cases by private clients and those that the Scotland Yard are unable to solve, along with his friend Dr. Watson.