13 years ago, four men met on the river working as rafting guides.

Homicide detective Melanie Hudson begins a torrid affair with a senator's son who is a suspect in a series of grisly murders.

The lives of head nurse Rachel Gunn and her co-workers at Little Innocence Hospital in Nebraska, where Rachel is often at odds with egotistical surgeon David Dunkel.

Widowed pediatrician Harry Weston is a miracle worker when it comes to dealing with his young patients, but he's more challenged by the other people surrounding him: daughters Barbara and Carol; his wisecracking office assistant, nurse LaVerne Todd; and obnoxious neighborhood mooch Charley Dietz. Thank goodness he always finds a friendly shoulder (and a warm, wet tongue) in Dreyfuss, his enormous dog.

Follow the intergalactic adventures of Capt. Jean-Luc Picard and his loyal crew aboard the all-new USS Enterprise NCC-1701D, as they explore new worlds.

Four Southern Florida seniors share a house, their dreams, and a whole lot of cheesecake. Bright, promiscuous, clueless and hilarious, these lovely, mismatched ladies form the perfect circle of friends.