Dave is a married man with two kids and a loving wife, and Mitch is a single man who is at the prime of his sexual life. One fateful night while Mitch and Dave are peeing in a fountain when lightning strikes, they switch bodies.

FBI agent Malcolm Turner and his 17-year-old son, Trent, go undercover at an all-girls performing arts school after Trent witnesses a murder. Posing as Big Momma and Charmaine, they must find the murderer before he finds them.