Rome is on the thresh-hold of the Holy year 1925, the city wishes to present itself as 'spotless' to the outside world. The appearance of a child's corpse puts an end to these aspirations. The police arrest a small time crook who has committed a robbery but has nothing to do with the murder of the child.

Ray Barone is a successful sportswriter living on Long Island with his wife Debra, daughter Ally, and twin sons, Geoffrey and Michael. That's the good news. The bad news? Ray's meddling parents, Frank and Marie, live directly across the street and embrace the motto "Su casa es mi casa," infiltrating their son's home to an extent unparalleled in television history.