Robert McCall finds himself at home in Southern Italy but he discovers his friends are under the control of local crime bosses. As events turn deadly, McCall knows what he has to do: become his friends' protector by taking on the mafia.

In Rome, the Cassamortari are people who work in the funeral business. The Pasti family's agency was founded by Giuseppe, who is willing to do anything to turn a corpse into money, preferably in black.

Giorgio is a young talented boxer who lives with his mother and dreams to became a champion.

Lino and Chicca are an aging, childless middle-class couple whose life is disrupted after he's diagnosed with Alzheimer's disease.

Follows a criminal gang in Rome that has a near monopoly of the city's heroin trade. Besides their internal feuding, the gang has to deal with the Camorra and Sicilian Mafia that both supply its heroin, the police led by Commissioner Scialoja and the Italian secret services.

Michele Casali is a middle-class professor in Fascist Italy who teaches at the same high school attended by his only daughter, Giovanna. A shy and sensitive girl, her insecurities are only magnified by Michele's overprotectiveness—reaching a point of no return.

When his destituite widowed sister-in-law—whom he had never stopped harbouring feelings for—and her ne'er-do-well son come to live with him after World War II, a mentally-ill farmer who spends all his time destroying unexploded ordnance scattered across the countryside finds a new purpose in his lonely life.

In 1863, Amsterdam Vallon returns to the Five Points of America to seek vengeance against the psychotic gangland kingpin, Bill the Butcher, who murdered his father years earlier. With an eager pickpocket by his side and a whole new army, Vallon fights his way to seek vengeance on the Butcher and restore peace in the area.

Two linen fabric dealers with their shops close to one another, battle against each other for more and more costumers. Umberto constantly loses clients because of the tough competition brought by Leone, who offers the best prices in the neighborhood. But they leave differences aside when the rise of Fascism places Anti-Semitic politics which rigidly control business like the one conducted by the Jewish Leone, and those new regulations are viewed by Umberto as completely unfair. The long rivalry soon becomes a great friendship.

Stella works in a restaurant in Rome. She feels frustrated about her life. In spite she has turned 40, she dreams of a film career.

Carabinieri's lieutenant Duilio Cordelli is in charge of investigating fake banknotes traffic. He discovers that a 60 billion lira bank robbery is linked with his case. Things get more complicated when the main suspected, Lorenzini, is killed. Moreover, Cordelli villa is blown up and the evidence points to the conclusion the whole case could be solved only by flying to London.

A police inspector is called to Milan to investigate a murder case since he grew up in the same ghetto as the suspect.