When a devastating attack shatters Mark Hogancamp and wipes away all memories, no one expected recovery. Putting together pieces from his old and new life, Mark meticulously creates a wondrous town named Marwen where he can heal and be heroic. As he builds an astonishing art installation — a testament to the most powerful women he knows — through his fantasy world, he draws strength to triumph in the real one.

A straight-laced pharmacist's uneventful life spirals out of control when he starts an affair with a trophy wife customer who takes him on a joyride involving sex, drugs and possibly murder.