In the Tenderloin neighborhood of San Francisco, a wounded Iraq War veteran is coaxed away from self-destructive behaviors by locals, including his son.

A successful physician and devoted family man, John Dolittle seems to have the world by the tail, until a long suppressed talent he possessed as a child, the ability to communicate with animals is suddenly reawakened with a vengeance! Now every creature within squawking distance wants the good doctor's advice, unleashing an outrageous chain of events that turns his world upside down!

In honor of his birthday, San Francisco banker Nicholas Van Orton, a financial genius and a cold-hearted loner, receives an unusual present from his younger brother, Conrad: a gift certificate to play a unique kind of game. In nary a nanosecond, Nicholas finds himself consumed by a dangerous set of ever-changing rules, unable to distinguish where the charade ends and reality begins.

An agoraphobic psychologist and a female detective must work together to take down a serial killer who copies serial killers from the past.

Longtime singles Lillian Lambert and Clifford Pepperman enjoy a romance late in their lives.