A drifter with unknown motives arrives in town and leaves a trail of dead bodies in his wake.

Through a series of vignettes, the often inexplicable behaviors of contemporary humans are observed and commented upon by a droll narrator. No matter how outlandish or senseless the action, one thing is certain: "It's Always Something."

When her boyfriend dumps Emily, a spontaneous woman in her 30s, she persuades her ultra-cautious mom to accompany her on a vacation to Ecuador. When these two very different women are trapped on this wild journey, their bond as mother and daughter is tested and strengthened while they attempt to navigate the jungle and escape.