In a series of escalating encounters, former security guard David Dunn uses his supernatural abilities to track Kevin Wendell Crumb, a disturbed man who has twenty-four personalities. Meanwhile, the shadowy presence of Elijah Price emerges as an orchestrator who holds secrets critical to both men.

An ordinary man makes an extraordinary discovery when a train accident leaves his fellow passengers dead — and him unscathed. The answer to this mystery could lie with the mysterious Elijah Price, a man who suffers from a disease that renders his bones as fragile as glass.