Dr. Bashir Hamed, a Syrian doctor with battle-tested skills in emergency medicine, makes the difficult decision to flee his country and build a new life in Canada with his younger sister Amira. Bash works to navigate a new environment after earning a coveted residency in the Emergency Department of one of the best hospitals in Toronto, York Memorial.

Journalist Fred Flarsky reunites with his childhood crush, Charlotte Field, now one of the most influential women in the world. As she prepares to make a run for the Presidency, Charlotte hires Fred as her speechwriter — much to the dismay of her trusted advisers.

A pair of high-frequency traders go up against their old boss in an effort to make millions in a fiber-optic cable deal.

When Anthony Sullivan disappears on his tenth birthday, his family is devastated. However, as more and more time passes without the police being able to locate him, long-buried family secrets are dragged to the surface, turning the Sullivan family against one another.

A couple's relationship is tested when uninvited guests arrive at their home, disrupting their tranquil existence.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.