Deo is a seasoned cop working for the NYPD. He is assigned a new partner, the novice agent Angela. During their twelve-hour shift, the two experience everything in the most dangerous streets of the city.

In 19th century Baltimore, Isabel Porter, a girl stricken with grief from her parents' untimely death, voluntarily checks herself into the Rosewood Institute. Subjected to bizarre and increasingly violent pseudo-scientific experiments in personality modification, brainwashing and mind control, she must escape the clutches of the Rosewood and exact her revenge, or else be forever lost.