A U.S. Marshal seeking justice for his brother's murder defends a small town from a corrupt Mayor and his henchmen with intents to revive the civil war.

Welcome to a place where being normal is really quite strange. In a remote Texas town no one is who they seem. From vampires and witches to psychics and hit men, Midnight is a mysterious safe haven for those who are different. As the town members fight off outside pressures from rowdy biker gangs, ever-suspicious cops and their own dangerous pasts, they band together and form a strong and unlikely family.

The stories of the men and women who work the overnight shift at San Antonio Memorial Hospital. They are an irreverent and special breed, particularly adrenaline junkie T.C. Callahan.