In early-1970s Las Vegas, Sam "Ace" Rothstein gets tapped by his bosses to head the Tangiers Casino. At first, he's a great success in the job, but over the years, problems with his loose-cannon enforcer Nicky Santoro, his ex-hustler wife Ginger, her con-artist ex Lester Diamond and a handful of corrupt politicians put Sam in ever-increasing danger.

The true story of Henry Hill, a half-Irish, half-Sicilian Brooklyn kid who is adopted by neighbourhood gangsters at an early age and climbs the ranks of a Mafia family under the guidance of Jimmy Conway.