Ichijo Zentaro, an inspector who is a trend junkie and loves to use out-of-fashion vocabulary used by high school girls, works together with Yuki Maria, a sharp-tongued inspector who has built up a stellar career at the MPD's first division, to solve a serial murder case.

After the end of the civil war that tore apart Japan, the new governors of Touto, Hokuto and Seito work together to reunify the country. However, they are actually members of an extraterrestrial race called the "Blood Tribe" (the same species as Evolto), who assumed their government positions as part of a plan to destroy Earth as they have done to Mars and other planets before. Considering Sento Kiryū (Kamen Rider Build) a major threat to their plans, the Blood Tribe manipulates his friends and other civilians into attacking him. With even his close ally Ryūga Banjō (Kamen Rider Cross-Z) now against him, Sento must fight to survive and stop the Blood Tribe's plan from succeeding.

The drama is set on the Twilight Express, Japan's longest overnight train service, which runs approximately 22 hours between Osaka and Sapporo. Nakayama and Sato play Chie and Keisuke, two lovers who have decided to part ways at the end of the journey. Chie already has a family but has been carrying on a passionate, secret affair with Keisuke. The story mainly takes place in their suite room on the train. The drama was filmed aboard the actual Twilight Express with cooperation from the JR West company, which operates the train service.

Takeshi Hongo is a promising young man with a passion for motorcycle racing. However, his dreams are suddenly ruined when he gets kidnapped by Shocker, the evil secret organization planning to dominate the world. After being remodeled into a cyborg, Takeshi escapes and swears to protect the world from the inhuman monsters.