A unique team, consisting of a federal agent, a police officer and a conspiracy theory novelist, investigate the shocking reappearance of Alcatraz's most notorious prisoners, fifty years after they supposedly vanished.

Carrie Remington seems like any other struggling waitress who's had a run of bad luck including a recent divorce. Things seem to be improving when she moves in with Ashley Dunnfield, a young woman from a wealthy background who's trying to make it on her own without assistance from her father, Richard. Ashley is thrilled when Carrie helps to win her father over, but when Carrie starts dating Richard, Ashley starts digging into her past and finds out that there is much she didn't know about her new roommate's sinister history.

FBI Special Agent Olivia Dunham, brilliant but formerly institutionalized scientist Walter Bishop and his scheming, reluctant son Peter uncover a deadly mystery involving a series of unbelievable events and realize they may be a part of a larger, more disturbing pattern that blurs the line between science fiction and technology.