10 years before the debut of the Ultimate Fighting Championship. In 1979, Bill Viola and Frank Caliguri dreamed up a contest pitting barroom bigmouths against wrestlers, martial artists, boxers, bouncers and brawlers, billed as no-holds-barred new type of competitive fighting. When the fights succeeded beyond their wildest expectations, they were swept up in a chain of events that ended in the first mixed-martial arts ban in the nation. “Tough Guys” chronicles the inception of Caliguri and Viola’s first bouts and the colorful, crazy cast of fighters who made them a hit as well as the politicians who brought it all crashing down. The film brings to life a moment when the national martial arts craze was building to a crescendo as the economies of Pennsylvania steel towns were plummeting to levels of unemployment never seen, breeding desperate men looking for a chance to prove their worth and make some money in the ring.

The youngest son of an alcoholic former boxer returns home, where he's trained by his father for competition in a mixed martial arts tournament – a path that puts the fighter on a collision course with his estranged, older brother.