John Lewis, a programming genius, has it all- a beautiful wife and a child, a lavish home and he's on the brink of making it big after he finishes one last project, a CD-Rom Sex Game called Virtual Girl. However, things get complicated when a woman in a VR simulation becomes “real” and falls in love with the VR system creator.

Five years after throwing a killer party and stealing Muffin away from alpha-male Zeta frat member Bud, head party nerd Ritchie is married (to Muffin!) and runs a detective agency.

Jerry tries to seduce his girlfriend Monica via hypnosis, but it accidentally makes her want to enter a convent and take a vow of chastity instead. Jerry tries to get her out by disguising himself as a priest and, later, a nun. Alas, his rescue attempt crosses paths with a mobster who's looking for his hidden stolen diamonds in the convent. Things get even more complicated when the pope himself decides to pay a surprise visit.