We meet Rosemary lying on the floor of her house, sobbing. Heartbroken. The doorbell rings. It's a Pizza Delivery Guy. Rosemary can't stop crying. She wants love, but it never works out. Fortunately for Rosemary, this Pizza Delivery Guy has the answer: forget about love and focus on wild random sex for once in her life. We cut to a fun slut-training montage where Pizza Delivery Guy teaches Rosemary his skanky ways and Rosemary learns to sexually liberate herself. Rosemary thinks she's mastered slut life, but her new skills are put to the test when she meets Ned.

Shy, sensitive April is the class virgin, torn between an illicit flirtation with her soccer coach Mr. B and an unrequited crush on sweet stoner Teddy. Emily, meanwhile, offers sexual favors to every boy to cross her path — including both Teddy and his best friend Fred, a live wire without filters or boundaries. As one high school party bleeds into the next — and April and Teddy struggle to admit their mutual affection — Fred's escalating recklessness starts to spiral into chaos.

A debt-ridden goofball on the run from the mob in Las Vegas falls for a roulette dealer.