In this film, childhood friends come face to face with the demons of rock and roll (lust, drugs, and passion) on a cross-country road trip that compels them to face their past, present, and future. Rocker Spyder, whose debut album was a huge hit saw his follow-on album bomb, causing him to retreat to his small hometown and give up. Seven years later, 27-year-old Spyder reconnects with his long-lost best friend and writer of his debut album Eric, son of a late great punk rock guitar legend, who has long settled into the sedate life of a suburban middle school music teacher. The reunion forces the two to recall their youthful ambitions and re-examine the choices they've made.

The story of sex, violence, race and rock and roll in 1950s Chicago, and the exciting but turbulent lives of some of America's musical legends, including Muddy Waters, Leonard Chess, Little Walter, Howlin' Wolf, Etta James and Chuck Berry.